Terumo Cardiovascular Group

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Platelet Therapy

The use of platelet therapy, including plasma sequestration and the procurement of concentrated, platelet-derived growth factors, is being adopted in cardiothoracic surgery to improve hemostasis and promote bone and wound healing.

Information provided on this website is not intended to make claims that the products are safe and effective for any use other than those explicitly described in the Instructions for Use. Clinicians should refer to the Instructions for Use or Owner's Manuals for complete information on the intended use of any product mentioned in this website.

CASE STUDY: Embrace Change or Face Extinction
As perfusion shifts from traditional cardiopulmonary bypass to a more general blood management focus, Al Stammers, CCP, Geisinger Medical Center, has increased his perfusion caseload through autotransfusion and platelet gel.

PROTOCOL: Improve sternal wound healing with platelet rich plasma.
Edward Woods, MD, Geisinger Clinic, explains that the use of platelet rich plasma is both clinically and economically justified.

STUDY: Cost Advantages Using Autologous Platelet Gel
An interview with Randy Brown, MD, Southeast Missouri Hospital. After a two-year study using platelet gel, the team lowered costs by reducing the need for expensive surgical glues, and eliminated costs associated with mediastinitis.

STUDY OVERVIEW: Autologous Platelet Gel Increases Tissue Phagocytic Capacity 2.5x in Diabetic Cardiac Surgery Patients
Dr. Gunaydin describes the importance of conducting a biomaterial evaluation to determine the mechanism by which platelet gel protects against sternal wound infection. (links to related publications)

PROTOCOL: Sample PRP/Platelet Gel Form
Sample form used by clinicians at Carolina Blood Management, Inc. AABB guidelines recommend that clinicians provide documentation for PRP or platelet gel procedures.

PROTOCOL: Fresenius C.A.T.S System Plasma Sequestration Protocol
The plasma sequestration protocol and process to help reduce blood and platelet transfusions during CPB at Mission St. Joseph's Hospital in Asheville, NC.

PROTOCOL: Clinical Updates in Platelet Gel: Sports Medicine
Minimally invasive percutaneous debridement with platelet gel protocol from Michael Scarpone, D.O.

RECOMMENDATIONS: 10 Tips for the First Year of a Platelet Gel Program
Tom Hankins, CCP, founder of a platelet gel program that performs 600-700 cases per year at Grant Medical Center, offers advice on beginning a program.

POSTER ABSTRACT: Autologous Platelet Gel for the Prevention of Sternal Wound Infection in Diabetic Patients Undergoing Bilateral Thoracic Artery Grafting. Gunaydin S et al. 45th Annual Meeting of the Society of Thoracic Surgeons 2009, San Francisco.
In the first STS presentation on the subject, the authors conclude that platelet gel seems to protect diabetic cardiac surgery patients against infection via growth factors and phagocytic capcity.

ABSTRACT: Use of Platelet Gel and Its Effects on Infection in Cardiac Surgery. JECT 2005;37: 381-386. Trowbridge, et al.
The authors demonstrate a significant reduction of sternal infection in patients receiving platelet gel. The Harvest SmartPRePĀ® 2 delivered the highest platelet concentration and yield compared to other devices.

ABSTRACT: Topical Application of Autologous Blood Products during Surgical Closure following a Coronary Artery Bypass Graft. European Journal of Cardiovascular Surgery, Aug 2008; Vol 34, 360-4. Khalafi, et al.
In this retrospective study of 1,446 cardiac surgery patients, the authors found that PRP application reduced the odds of chest infection by 93%, chest drainage by 96% and leg wound drainage by 88%.

ABSTRACT: Clinical Impact and Biomaterial Evaluation of Autologous Platelet Gel in Cardiac Surgery. Perfusion 2008; 23: 179-186. Gunaydin S et al.
In a prospective, randomized, 64-patient study, the authors determine that autologous platelet gel was superior to gelatine in its effects on hemostasis, wound healing, and resistance to infection.

ABSTRACT: The Use of Autologous Platelet Gel to Treat Difficult-to-Heal-Wounds: A Pilot Study. Transfusion Practice 2004;44. Mazzucco, et al.
This study evaluated the use of PRP to heal sternal wounds and necrotic ulcers and found patients with dehiscent sternal wounds achieved 100% healing in half the time.

ABSTRACT: The Efficacy of Autologous Platelet Gel in Pain Control and Blood Loss in Total Knee Arthroplasty. International Orthopedics. April 2006. 10.1007/s00264-006-0174z. Gardner, et al.
This study indicates that the application of autologous platelet gel may lead to improved haemostasis, better pain control and a shortened hospital stay.