Terumo Cardiovascular Group

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Blood Management

Information provided on this website is not intended to make claims that the products are safe and effective for any use other than those explicitly described in the Instructions for Use. Clinicians should refer to the Instructions for Use or Owner's Manuals for complete information on the intended use of any product mentioned in this website.

STUDY OVERVIEW: Study Demonstrates That Low Prime Volume Oxygenator Significantly Reduces Hemodilution
A study published in Perfusion confirms the beneficial effects of reducing circuit prime volume to reduce hemodilution during CPB.

BEST PRACTICE: Experts Share Tips To Achieve Blood Savings
Industry experts present clinical topics that are top-of-mind for perfusionists and the highlights are shared in this article.

BEST PRACTICE: STS Blood Conservation Revision 2011
The STS Blood Conservation Guideline Task Force released its new 2011 practice guidelines: 2011 Update to The Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists Blood Conservation Clinical Practice Guidelines.

SYNOPSIS: European Team Outlines Benefits Of Minimized Perfusion Circuit
At the Optimizing Cardiac Surgery Symposium on March 5, 2010, Uwe Schonrock, CCP, Klinikum Braunschweig, shared the clinical benefits of his team's use of the ROCSafe Hybrid Perfusion System in 2,500 cases.

CASE STUDY: Bloodless Surgery for Pediatric Cardiac Surgery Patients
Dave Fitzgerald, CCP, describes how the INOVA Fairfax Hospital team has adopted Jehovahs Witnesses blood management strategies for all patients- adults and pediatric.

CASE STUDY: Bloodless Cardiac Surgery is a Team Sport
Ninety percent of patients weighing over 25 kilos have surgery without receiving blood at The Heart Center at Nationwide Children's Hospital in Columbus, Ohio. Read about its blood management program.

CASE STUDY: High Flow, Low Prime Oxygenator Contributes to Blood Management Program
Jeffrey Wilson, CCP, describes how the perfusion team at St. Joseph Hospital Center achieved a significant reduction in prime volume using CAPIOX RX Oxygenators and blood management strategies.

STUDY: Children's Hospital Studies New Oxygenator with Integrated Arterial Filter
Joseph Deptula, CCP, Children's Hospital, found that the CAPIOX FX05 Oxygenator significantly reduced CPB prime volumes and surface area while reducing blood donor exposure; all without compromising patient safety.

PROTOCOL: Fresenius C.A.T.S System Plasma Sequestration Protocol
The plasma sequestration protocol and process to help reduce blood and platelet transfusions during CPB at Mission St. Joseph's Hospital in Asheville, NC.

CASE STUDY: Pediatric Blood Management Program Optimal With 3-Year-Olds
Medical College of Georgia Health Children's Medical Center uses smaller tubing and oxygenator to eliminate 200 ml of prime volume to benefit three-year-old patients.

SUMMARY: Blood Management: In 2008, everyone was talking about it. In 2009, everyone wants to do it.
In an interview,Timothy Hannon, MD, reviews the highlights from his presentation at the 2009 Optimizing Cardiac Surgery Symposia, focusing on the need for clinician education.

POWERPOINT: The Benefits of Using a Remote Pump System for Children Undergoing Open Heart Surgery
Todd Smyre, CCP, offers his findings on blood conservation using a remote mounted pump for children undergoing open heart surgery at an Optimizing Cardiac Surgery Symposia in April 2005.

CD-ROM: CSI Perfusion: Discovering the Evidence for Effective Blood Management
David Fitzgerald, CCP, shares results from the blood management program at Inova Heart and Vascular Institute at the Optimizing Cardiac Surgery Symposium in Orlando in May 2009.

CD-ROM: Blood Management: In 2008, everyone was talking about it. In 2009, everyone wants to do it.
In his presentation at the 2009 Optimizing Cardiac Surgery Symposia, Timothy Hannon, MD, provides a realistic definition of blood management and a discussion of issues driving its growing adoption.

JOURNAL ARTICLE: Report from AmSECT's International Consortium for Evidence-Based Perfusion: AmSECT Standards and Guidelines for Perfusion Practice: 2013. JECT. 2013; 45:156-166. Baker, R, et al. (PDF)

CLINICAL STUDY: Prescriptive Patient Extracorporeal Circuit and Oxygenator Sizing Reduces Hemodilution and Allogeneic Blood Product Transfusion during Adult Cardiac Surgery. JECT. 2013; 45:167-172. Bronson S, et al. (PDF)

JOURNAL ARTICLE: Report from AmSECT's International Consortium for Evidence-Based Perfusion: AmSECT Standards and Guidelines for Perfusion Practice: 2013. JECT. 2013; 45:156-166. Baker, R, et al. (PDF)

ABSTRACT: Beneficial Effects of Modern Perfusion Concepts in Aortic Valve and Aortic Root Surgery. Perfusion 2009;24: 37-44, Kutschka, et al.
In this 170-patient study, the use of the ROCSafe™ Hybrid Perfusion System was found to reduce side effects of standard extracorporeal circulation.

ABSTRACT: A New Minimized Perfusion Circuit Provides Highly Effective Ultrasound Controlled Deairing. Artificial Organs. 2007 Mar; 31(3):215-220, Kutschka, et al.
This study compared a ROCSafe™ Hybrid Perfusion System to conventional perfusion circuit and results indicated that active venous deairing was significantly reduced compared to passive deairing on a conventional circuit.

ABSTRACT: Blood Separation with Two Different Autotransfusion Devices: Effects on Blood Cell Quality and Coagulation Variables. Int. J Artif Organs, Dec 1998; 2: 820-4. Rosalski, et al.
The authors compare the Fresenius C.A.T.S System with another device and found that C.A.T.S had a higher platelet recovery rate and higher platelet concentration.

ABSTRACT Implementation of the Continuous AutoTransfusion System (C.A.T.S) in Open Abdominal Aortic Aneurysm Repair: An Observational Comparative Cohort Study. Vascular and Endovascular Surgery, Feb-March 2008; Vol. 42, 32-39, Tawfick, W, et al.
In 187 patients, who underwent AAA, the authors found the Fresenius C.A.T.S system reduced the amount of blood transfused, was associated with reduced ICU and hospital stay, and was cost effective.

ABSTRACT: Levels of Inflammatory Markers in the Blood Processed by Autotransfusion Devices during Cardiac Surgery Associated with Cardiopulmonary Bypass Circuit. Perfusion 2002; 17:117-123. Amand, et al.
This study evaluates the ability of several cell salvage devices to remove white cells. The C.A.T.S System and Haemonetics CS5 devices removed the highest percentage of white cells.

ABSTRACT: Bloodless Cardiac Surgery and the Pediatric Patient: A Case Study. Perfusion 2008; 23: 131-134. Ging, AL et al.
The authors present blood management strategies in which a 5.9 kg Jehovah's Witness patient underwent successful correction of a VSD without the use of transfusions.

ABSTRACT: Quality of Processed Blood for Autotransfusion. JECT March 2000; 32: 11-9. Shulman, et al.
The authors evaluate the quality of processed blood using several parameters and demonstrate that the C.A.T.S System has a high washout efficiency and produces consistently high HCT at high flow rates.

ABSTRACT: The Efficacy of Autologous Platelet Gel in Pain Control and Blood Loss in Total Knee Arthroplasty. International Orthopedics. April 2006. 10.1007/s00264-006-0174z. Gardner, et al.
This study indicates that the application of autologous platelet gel may lead to improved haemostasis, better pain control and a shortened hospital stay.

ABSTRACT: Intraoperative Autotransfusion in Small Children: An In-vitro Investigation to Study its Feasability. Anesth Analg, April 1999; 88(4): 763-6. Booke, et al.
This in-vitro study demonstrates the ability of the Fresenius C.A.T.S System to produce high quality HCT independent of blood volume suggesting the feasability of IAT in small children.

ABSTRACT: A Review of Leukofiltration in Cardiac Surgery: The Time Course of Reperfusion Injury may Facilitate Study Design of Anti-Inflammatory Effects. Perfusion 2002; 17: 53-62. Ortolano, et al.
The authors address the effects of systemic inflammatory response syndrome (SIRS) during CPB, and provide a review of leukocyte filtration literature.

ABSTRACT: Non-Pharmacologic Therapeutic Strategies for Reducing Complications of Cardiopulmonary Bypass. Filtration 2005; 1(2):95-106. Gunaydin S, et al.
This study of 225 patients undergoing CPB concludes that the use of circuits with leukocyte filtration and Xcoating provides clinically significant benefits for high risk patients.

ABSTRACT: Investigation of Blood Compatibility of PMEA-Coated Extracorporeal Circuits. Journal of Bioactive and Compatible Polymers, Vol 17, Sept 2002. Kocakulak M, et al.
In a study comparing PMEA-coated and uncoated oxygenators, the authors found greater retention of clotting factors and platelets and less post-op hemorrhaging when using PMEA-coated oxygenators.

ABSTRACT: Emerging Technologies in Biocompatible Surface Modifying Additives: Quest for Physiologic CPB. Cardiovascular and Hematological Agents. 2004; Vol. 2:No 4. Gunaydin S, et al.
The authors compare surface coatings, including Xcoating, in 155 CPB cases for chemical composition, biomaterial evaluation and clinical efficacy.

ABSTRACT: The CAPIOX RX05 Oxygenator: Pediatric Clinical Observations. Perfusion. 2003;18, 321-323, Tinius, et al.
The authors provide clinical observations on the use of the CAPIOX® BABY RX™ Oxygenator and reducing prime volume in neonate circuits.

ABSTRACT: Biocompatibility of Poly (2-methoxyethylacrylate) Coating for Cardiopulmonary Bypass. Annals Thoracic Cardiovascular Surgery, 2003, Volume 9, No 1. Noguchi, et al.
The authors compare the biocompatibility of PMEA-coated and heparin-coated circuits by measuring several inflammatory markers. Results indicate PMEA-coated circuits are as biocompatible as heparin coated circuits.

ABSTRACT: Xcoating: A New Biopassive Polymer Coating. Canadian Perfusion Canadienne, Volume 11, No 2, June 2001. Schiel, et al.
This paper explains the mechanism and benefits of Xcoating.

ANIMATION: Prescriptive Oxygenation 3-D Animation
This animation illustrates how Terumo's unique oxygenators, packaging solutions and brackets make implementing Prescriptive Oxygenation quick and convenient.